Contraindicated (one)pentobarbital will lower the extent or effect of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with robust CYP3A4 inducers can result in lowered serum concentrations and loss of antimalarial efficacy

pentobarbital will lower the level or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

pentobarbital will lower the level or effect of exemestane by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. For sufferers acquiring exemestane with a strong CYP3A4 inducer the suggested dose of exemestane is 50 mg everyday following a food.

pentobarbital will decrease the level or effect of fedratinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Effect of coadministering a solid CYP3A4 inducer with fedratinib hasn't been analyzed.

pentobarbital will minimize the level or effect of midostaurin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Robust CYP3A4 inducers may well lower midostaurin concentrations causing lowered efficacy.

pentobarbital will lessen the extent or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. The efficacy of hormonal contraceptives might be lessened. Use of a nonhormonal contraceptive is suggested.

Check Carefully (1)pentobarbital will minimize the extent or effect of hydrocodone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Warning when discontinuing CYP3A4 inducers that are coadministered with hydrocodone; plasma concentrations of hydrocodone may enhance and may lead to probably lethal respiratory depressionSerious - Use Alternative (1)hydrocodone, pentobarbital.

pentobarbital will minimize the level or effect of almotriptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

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pentobarbital will decrease the level or effect of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Powerful or reasonable CYP3A4 inducers considerably cut down guanfacine plasma concentrations and elimination half-life.

Griseofulvin: Phenobarbital seems to interfere with the absorption of orally administered griseofulvin, So lowering its blood amount.

fentanyl intranasal and pentobarbital each raise sedation. Stay clear of or Use Alternate Drug. Limit use to sufferers for whom alternative cure solutions are inadequate

Check Closely (one)pentobarbital will minimize the extent or effect of glecaprevir/pibrentasvir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will reduce the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.